Article

A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

2021-06-22

Abstract excerpt

Mosaic loss of Y chromosome (LOY) in leukocytes is associated with risk for death and disease in men. We investigated a polygenic risk score (PRS) for LOY comprising 156 previously associated germline variants, in 5131 men aged ≥70 years. Levels of LOY were estimated using microarrays and validated by whole genome sequencing. After adjusting for covariates, the PRS was a significant predictor of LOY (odds ratio 1....

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Literature Corpus work: 85a343d4-87ae-58e4-a5f3-4fbd1d7cf6da
DOI: 10.1101/2021.06.15.21258995

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