Article

Intra-individual changes in the frequency of mosaic loss of chromosome Y over time estimated with a new method

2019-05-09

Abstract excerpt

<h4>Background</h4> Mosaic loss of chromosome Y (LOY) is the most common somatic mutation and is associated with all-cause mortality, non-haematological cancers and Alzheimer’s disease among other outcomes. The predominant method used for estimating LOY is the intensity data generated by SNP-arrays, which is difficult to interpret due to its logarithmic scale. Here we describe a new way to convert the LOY mosaici...

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Literature Corpus work: a482d808-7c0f-5ab0-b760-1890565fb142
DOI: 10.1101/631713

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