Article
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
Cancer cell - 16 Aug 2011
Chen Muhan, Pratt Christopher P, Zeeman Martha E, Schultz Nikolaus, Taylor Barry S, O'Neill Audrey, Castillo-Martin Mireia, Nowak Dawid G, Naguib Adam, Grace Danielle M, Murn Jernej, Navin Nick, Atwal Gurinder S, Sander Chris, Gerald William L, Cordon-Cardo Carlos, Newton Alexandra C, Carver Brett S, Trotman Lloyd C
Abstract excerpt
Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate. This genetic setting initially triggers a growth suppressive response via p53 and the Phlpp2 ortholog, and reveals spontaneous Trp53 inactivation...
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