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Article

PTEN: Multiple Functions in Human Malignant Tumors

16 Feb 2015

Abstract excerpt

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor suppressor in a PI3K-independent manner. Indeed, the PTEN network regulates a broad spectrum of biological functions, modulating the flow of information from membrane-bound growth factor receptors to nuclear transcription factors,...

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Identifiers

PMID: 25763354
DOI: 10.3389/fonc.2015.00024

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