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Article

PTEN

2 Jun 2014

Abstract excerpt

The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation. As such, PTEN regulates many cellular processes, including proliferation, survival, energy metabolism, cellular architecture, and motility. More than a decade of research has expanded our...

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PMID: 24905788
DOI: 10.1146/annurev-biochem-082411-113907

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