Article
The functions and regulation of the PTEN tumour suppressor.
Nature reviews. Molecular cell biology - 4 Apr 2012
Song Min Sup, Salmena Leonardo, Pandolfi Pier Paolo
Abstract excerpt
The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture....
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