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Article

Therapeutic targeting of cancers with loss of PTEN function.

Current drug targets - 1 Jan 2014

Dillon Lloye M, Miller Todd W

Abstract excerpt

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is one of the most frequently disrupted tumor suppressors in cancer. The lipid phosphatase activity of PTEN antagonizes the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway to repress tumor cell growth and survival. In the nucleus, PTEN promotes chromosome stability and DNA repair. Consequently, loss of PTEN function increases genomic...

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Topics

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Share to Epigenesis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

Share to PTEN Phosphohydrolase

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Source

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Identifiers

PMID: 24387334
DOI: 10.2174/1389450114666140106100909
PMCID: PMC4310752

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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