Back to search

Article

3D bioengineered neural tissue generated from patient-derived iPSCs develops time-dependent phenotypes and transcriptional features of Alzheimer’s disease

2022-07-22

Abstract excerpt

<h4>Background</h4> Current models to study Alzheimer’s disease (AD) include cell cultures and animal models. Human diseases, however, are often poorly reproduced in animal models. Developing techniques to differentiate human brain cells from induced pluripotent stem cells (iPSCs) provides a novel approach to studying AD. Three-dimensional (3D) cultures to model AD are represented by organoids, neurospheroids, an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6b2f8689-d6ce-5574-b812-36c62bc574f0
DOI
10.1101/2022.07.21.501004
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
3D bioengineered neural tissue generated from patient-derived iPSCs develops time-dependent phenotypes and transcriptional features of Alzheimer’s diseaseDOI 10.1101/2022.07.21.501004
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.Semantic proximity
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.Semantic proximity
Generation of an Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with an APP Gene MutationSemantic proximity
Reprogramming the Brain—iPSC Models Illuminating the Pathogenesis and Treatment of Alzheimer’s Disease and Other DementiasSemantic proximity
Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.Semantic proximity
A 3D human neural cell culture system for modeling Alzheimer's disease.Semantic proximity
Stem Cell Therapies in Alzheimer’s Disease: Applications for Disease ModelingSemantic proximity
A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosisSemantic proximity
Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegenerationSemantic proximity
Investigating Connectivity Deficits in Alzheimer’s Disease Using a Novel 3D Bioprinted Model Designed to Quantify Neurite OutgrowthSemantic proximity
Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsSemantic proximity
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.Semantic proximity
Select a neighboring publication to make it the new centre.