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Article

3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.

Molecular psychiatry - 1 Dec 2023

Lomoio Selene, Pandey Ravi S, Rouleau Nicolas, Menicacci Beatrice, Kim WonHee, Cantley William L, Haydon Philip G, Bennett David A, Young-Pearse Tracy L, Carter Gregory W, Kaplan David L, Tesco Giuseppina

Abstract excerpt

Several iPSC-derived three-dimensional (3D) cultures have been generated to model Alzheimer's disease (AD). While some AD-related phenotypes have been identified across these cultures, none of them could recapitulate multiple AD-related hallmarks in one model. To date, the transcriptomic features of these 3D models have not been compared with those of human AD brains. However, these data are crucial to...

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PMID: 37365240
DOI: 10.1038/s41380-023-02147-3
PMCID: PMC11164539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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