Back to search

Article

Investigating Connectivity Deficits in Alzheimer’s Disease Using a Novel 3D Bioprinted Model Designed to Quantify Neurite Outgrowth

2025-02-04

Abstract excerpt

Here we present a novel 3D bioprinted model of the forebrain cortex designed to quantify neurite outgrowth across a hydrogel bridge. To validate this model, we cultured Alzheimer’s disease (AD) forebrain cortical populations derived from human iPSCs carrying APP (amyloid precursor protein) mutations (K670M/N671L + V717F). Neurite and synapse formation were significantly impaired in 3D AD mutant cultures compared t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
afe73476-073b-5a14-8052-d2c53b721846
DOI
10.20944/preprints202502.0233.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Investigating Connectivity Deficits in Alzheimer’s Disease Using a Novel 3D Bioprinted Model Designed to Quantify Neurite OutgrowthDOI 10.20944/preprints202502.0233.v1
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.Semantic proximity
3D bioengineered neural tissue generated from patient-derived iPSCs develops time-dependent phenotypes and transcriptional features of Alzheimer’s diseaseSemantic proximity
A 3D human neural cell culture system for modeling Alzheimer's disease.Semantic proximity
3D biocomposite culture enhances differentiation of dopamine-like neurons from SH-SY5Y cells: A model for studying Parkinson's disease phenotypes.Semantic proximity
Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegenerationSemantic proximity
The Shift from 2D to 3D Cell Culture in Neurobiology: Implications for Precision Medicine and Organ-on-Chip TechnologiesSemantic proximity
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesisSemantic proximity
Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture modelSemantic proximity
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.Semantic proximity
Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.Semantic proximity
Pushing the boundaries of brain organoids to study Alzheimer's disease.Semantic proximity
Aging phenotype in AD brain organoids: Track to success and challenges.Semantic proximity
Select a neighboring publication to make it the new centre.