Article

The Autism Risk Factor CHD8 Is a Chromatin Activator in Human Neurons and Functionally Dependent on the ERK-MAPK Pathway Effector ELK1

2021-08-18

Abstract excerpt

The chromodomain helicase DNA-binding protein CHD8 is among the most frequently found de-novo mutations in autism spectrum disorder (ASD) 1-4 . Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is believed to be a chromatin regulator, but mechanisms for its genomic targeting is also unclear. To elucidate the role of CHD8 in human neurons, we generated...

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Literature Corpus work: f5e1ccc1-2d89-53ba-9fab-931cf6756ab5
DOI: 10.21203/rs.3.rs-799225/v1

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