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Article

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014

Sugathan Aarathi, Biagioli Marta, Golzio Christelle, Erdin Serkan, Blumenthal Ian, Manavalan Poornima, Ragavendran Ashok, Brand Harrison, Lucente Diane, Miles Judith, Sheridan Steven D, Stortchevoi Alexei, Kellis Manolis, Haggarty Stephen J, Katsanis Nicholas, Gusella James F, Talkowski Michael E

Abstract excerpt

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural progenitor cells (NPCs) by reducing its expression and then integrating transcriptome sequencing (RNA...

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Identifiers

PMID: 25294932
DOI: 10.1073/pnas.1405266111
PMCID: PMC4210312

Genes

CHD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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