Article

The Autism Risk Factor CHD8 Is a Chromatin Activator in Human Neurons and Functionally Dependent on the ERK-MAPK Pathway Effector ELK1

2020-11-10

Abstract excerpt

The chromodomain helicase DNA-binding protein CHD8 is among the most frequently found de-novo mutations in autism spectrum disorder (ASD) 1–4 . Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is believed to be a chromatin regulator, but mechanisms for its genomic targeting is also unclear. To elucidate the role of CHD8 in human neurons, we generated...

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Literature Corpus work: 743daa06-4b3d-5e6b-8225-bf257a8ec1fe
DOI: 10.1101/2020.11.10.377010

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