Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

CHD8 dysregulation in neurodevelopment: Emerging insights into autism pathophysiology.

International journal of biological macromolecules - 1 Jan 2026

Chatterjee Dhrita, Maparu Kousik

Abstract excerpt

Autism is considered a multifaceted neurodevelopmental condition, marked by impairments in social interaction, communication, and repetitive behaviours. Recent genetic research has highlighted mutations in the CHD8 (Chromodomain Helicase DNA-binding Protein 8) gene as one of the most significant risk factors associated with ASD. CHD8 encodes a chromatin remodeler protein that regulates gene expression by altering...

Topics

Humans
Animals
DNA-Binding Proteins
Transcription Factors
Autistic Disorder
Mutation
Brain

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41485656
DOI: 10.1016/j.ijbiomac.2025.149985

Genes

CHD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHD8 dysregulation in neurodevelopment: Emerging insights into autism pathophysiology.PMID 41485656Read ↗

The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders.Semantic proximity Read ↗

Neurodevelopmental functions of CHD8: new insights and questions.Semantic proximity Read ↗

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.Semantic proximity Read ↗

De novo variants in the Helicase-C domain of CHD8 are associated with severe phenotypes including autism, language disability and overgrowth.Semantic proximity Read ↗

[Progress in autism: de novo mutation and CHD8 functions].Semantic proximity Read ↗

A Novel Variant of the CHD8 Gene in a Patient with Autism Spectrum Disorder.Semantic proximity Read ↗

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life.Semantic proximity Read ↗

The complex etiology of autism spectrum disorder due to missense mutations of CHD8.Semantic proximity Read ↗

CHD8 intragenic deletion associated with autism spectrum disorder.Semantic proximity Read ↗

A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review.Semantic proximity Read ↗

Expansion of phenotypic and genotypic data in autism spectrum disorders due to variants in the CHD8 gene.Semantic proximity Read ↗

CHD8 Regulates Cellular Homeostasis and Neuronal Function Genes Across Multiple Models of <i>CHD8</i> HaploinsufficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.