Article

Non-monotonic regulation of gene expression, neural progenitor fate and brain growth by the chromatin remodeller CHD8

2018-11-12

Abstract excerpt

<h4>Summary</h4> Heterozygous CHD8 mutations are associated with autism and macrocephaly with high penetrance in the human population. The reported mutations may have loss-of-function (haploinsufficient), hypomorphic or dominant negative effects on protein function. To determine the effects of reducing CHD8 protein function below haploinsufficient levels on brain development, we established a Chd8 allelic serie...

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Literature Corpus work: 07f1fbad-3f6f-5b2d-88a4-8985c4c23b36
DOI: 10.1101/469031

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