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Article

Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations.

Genome research - 1 Oct 2012

Pinter Stefan F, Sadreyev Ruslan I, Yildirim Eda, Jeon Yesu, Ohsumi Toshiro K, Borowsky Mark, Lee Jeannie T

Abstract excerpt

X chromosome inactivation (XCI) achieves dosage balance in mammals by repressing one of two X chromosomes in females. During XCI, the long noncoding Xist RNA and Polycomb proteins spread along the inactive X (Xi) to initiate chromosome-wide silencing. Although inactivation is known to commence at...

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Source

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Identifiers

PMID: 22948768
DOI: 10.1101/gr.133751.111
PMCID: PMC3460182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22948768-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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