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Article

Polycomb repressive complex 2 in an autoinhibited state.

The Journal of biological chemistry - 11 Aug 2017

Bratkowski Matthew, Yang Xin, Liu Xin

Abstract excerpt

Polycomb-group proteins control many fundamental biological processes, such as anatomical development in mammals and vernalization in plants. Polycomb repressive complex 2 (PRC2) is responsible for methylation of histone H3 lysine 27 (H3K27), and trimethylated H3K27 (H3K27me3) is implicated in epigenetic gene silencing. Recent genomic, biochemical, and structural data indicate that PRC2 is broadly conserved from...

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Identifiers

PMID: 28607149
DOI: 10.1074/jbc.M117.787572
PMCID: PMC5555192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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