Article

Discrete DNA integration events during Bridge-Induced Translocation generate partial chromosomal deletions and differential aneuploidy in Saccharomyces cerevisiae

2010-01-01

Abstract excerpt

Chromosome aberrations and genome instability have a long history of being associated with human genetic diseases, including cancer. The feasibility to drastically reshape the genome with a single chromosomal translocation also gives this molecular event a powerful capacity to drive evolution. To date, numerous assays have been developed to study gross chromosomal rearrangements (GCRs), although the molecular mech...

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Literature Corpus work: 6a9c9d20-50d3-594d-838d-1879ead5f712
DOI: 10.21954/ou.ro.0000f203

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