Patching broken chromosomes with extranuclear cellular DNA.

doi:10.1016/s1097-2765(00)80397-4

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Article

Patching broken chromosomes with extranuclear cellular DNA.

Molecular cell - 1 Nov 1999

Yu X, Gabriel A

Abstract excerpt

Chromosomal double-strand breaks (DSBs) can be repaired by either homology-dependent or homology-independent pathways. Using a novel intron-based genetic assay to identify rare homology-independent DNA rearrangements associated with repair of a chromosomal DSB in S. cerevisiae, we observed that approximately 20% of rearrangements involved endogenous DNA insertions at the break site. We have analyzed 37 inserts...

Topics

Base Sequence
Cell Nucleus
Chromosome Breakage
Chromosomes, Fungal
DNA Repair
DNA, Fungal
DNA, Mitochondrial
Deoxyribonucleases, Type II Site-Specific
Enzyme Induction
Evolution, Molecular
Galactose
Genes, Fungal
Introns
Molecular Weight
Mutation
Recombination, Genetic
Retroelements
Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 10619034
DOI: 10.1016/s1097-2765(00)80397-4

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