Article

Revisiting the role of the spindle assembly checkpoint in the formation of gross chromosomal rearrangements in <i>Saccharomyces cerevisiae</i>

2024-04-13

Abstract excerpt

Multiple pathways are known to suppress the formation of gross chromosomal rearrangements (GCRs), which can cause human diseases including cancer. In contrast, much less is known about pathways that promote their formation. The spindle assembly checkpoint (SAC), which ensures the proper separation of chromosomes during mitosis, has been reported to promote GCR, possibly by delaying mitosis to allow GCR-inducing DN...

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Literature Corpus work: 961aa7ee-35ad-5324-85fa-4ac955d84610
DOI: 10.1101/2024.04.11.589040

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