Article

Mitotic gene conversion tracts associated with repair of a defined double-strand break in <i>Saccharomyces cerevisiae</i>

2017-04-28

Abstract excerpt

Mitotic recombination between homologous chromosomes can lead to loss-of-heterozygosity (LOH), which is an important contributor to human disease. In the current study, a defined double-strand break (DSB) on chromosome IV was used to initiate LOH in a yeast strain with sequence-diverged chromosomes. Associated gene conversion tracts, which reflect the repair of mismatches formed when diverged chromosomes exchange...

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Literature Corpus work: 2d4e728f-c519-5109-8838-d880adc4d9fc
DOI: 10.1101/132167

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