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Nicking Loop™: An infinite amplification of single-stranded circular DNA

2025-05-09

Abstract excerpt

Circular single-stranded DNA (CssDNA) offers unique advantages for molecular diagnostics and next-generation sequencing (NGS) due to its nuclease resistance and compatibility with rolling circle amplification. We present the Nicking Loop™, a novel and versatile method for converting both single- and double-stranded DNA into CssDNA and enabling robust, unbiased amplification. This technique preserves the original D...

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Literature Corpus work
fd10e2f0-aa8b-5991-8ca5-735f2e48461b
DOI
10.1101/2025.05.08.652165
Open publication

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Nicking Loop™: An infinite amplification of single-stranded circular DNADOI 10.1101/2025.05.08.652165
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