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Article

Detection of single-base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation.

Analytical biochemistry - 15 Jul 2011

Park Kkothanahreum, Choi Bo-Ra, Kim Yea Seul, Shin Seonmi, Hah Sang Soo, Jung Woong, Oh Sangtaek, Kim Dong-Eun

Abstract excerpt

A single nucleotide polymorphism (SNP) is a common genetic variation when a single nucleotide differs between members of a species or paired chromosome. Due to its association with disease susceptibility and drug resistance, SNP detection is of great value in studying the variation in drug responses. Here we present two quantitative SNP detection methods for a single-base mismatch in RNA, based on nick-joining...

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PMID: 21453671
DOI: 10.1016/j.ab.2011.03.028

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