Article

Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants

2026-06-11

Abstract excerpt

Apolipoprotein E (ApoE) is the primary genetic risk modifier of late-onset Alzheimer’s disease, with the ε4 allele increasing risk up to 15-fold relative to ε3. The structural differences between isoforms are thought to underlie their distinct effects on lipid transport, receptor binding, and disease risk. ApoE4 exhibits reduced thermodynamic stability compared to ApoE3, but prior characterisation has relied on pu...

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Literature Corpus work: 6a8b1a9e-f052-51c1-b272-3f729a713ab2
DOI: 10.64898/2026.06.09.730809

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