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Article

HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective.

Journal of the American Chemical Society - 3 Aug 2016

Chu Qian, Diedrich Jolene K, Vaughan Joan M, Donaldson Cynthia J, Nunn Michael F, Lee Kuo-Fen, Saghatelian Alan

Abstract excerpt

Apolipoprotein E (ApoE) belongs to a large class of proteins that solubilize lipids for physiological transport. Humans have three different APOE alleles, APOE ε2, APOE ε3, and APOE ε4, and genetic studies identified ApoE4 as the strongest genetic risk factor for Alzheimer's disease (AD). People who are homozygous for ApoE4 (i.e., ApoE4/E4) are an order of magnitude more likely to develop late-onset AD (LOAD)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Temperature Requirement A Serine Peptidase 1

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Source

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Identifiers

PMID: 27379525
DOI: 10.1021/jacs.6b03463
PMCID: PMC5063305

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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