Article

APOE Isoform-Dependent Self-Association Measured by a Split-Luciferase Complementation Assay: Differential Effects of Disease-Risk and Protective Variants

2026-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Apolipoprotein E (ApoE) is the principal lipid transport protein in the central nervous system and the strongest genetic modifier of late-onset Alzheimer’s disease (AD) risk. The three common isoforms, ApoE2, ApoE3, and ApoE4, differ in their propensity to self-associate, with ApoE4 forming oligomers more readily than ApoE3 or ApoE2. This enhanced self-association is proposed to reduce the pool...

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Literature Corpus work: cd79fd5b-64c8-582a-b875-fe0c32467e25
DOI: 10.64898/2026.05.09.26352797

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