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Article

Age-dependent accumulation of tau aggregation in Caenorhabditis elegans

19 Aug 2022

Abstract excerpt

Aging is the primary risk factor for Alzheimer’s disease (AD) and related disorders (ADRDs). Tau aggregation is a hallmark of AD and other tauopathies. Even in normal aging, tau aggregation is found in brains, but in disease states, significantly more aggregated tau is present in brain regions demonstrating synaptic degeneration and neuronal loss. It is unclear how tau aggregation and aging interact to give rise...

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PMID: 36062211
DOI: 10.3389/fragi.2022.928574

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