Article

<i>APP</i> -induced patterned neurodegeneration exacerbated by <i>APOE4</i> in <i>C. elegans</i>

2018-07-24

Abstract excerpt

Genetic and epidemiological studies have found that variations in the amyloid precursor protein ( APP ) and the apoliopoprotein E ( APOE ) genes represent major modifiers of the progressive neurodegeneration in Alzheimer’s disease (AD). An extra copy or gain-of-function mutations in APP lower age of AD onset. Compared to the other isoforms ( APOE3 and APOE2 ), the ε4 allele of APOE ( APOE4 ) hastens and exa...

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Literature Corpus work: 319cca33-02e3-5ecb-a70d-2ef2ff17fbe1
DOI: 10.1101/376095

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