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APP -Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans

24 Jun 2020

Abstract excerpt

Abstract Genetic and epidemiological studies have found that variations in the amyloid precursor protein (APP) and the apoliopoprotein E (APOE) genes represent major modifiers of the progressive neurodegeneration in Alzheimer’s disease (AD). An extra copy of or gain-of-function mutations in APP correlate with early onset AD. Compared to the other variants (APOE2 and APOE3), the ε4 allele of APOE (APOE4) hastens...

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PMID: 32580938
DOI: 10.1534/g3.120.401486

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