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Article

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

1 Jan 2019

Abstract excerpt

Allele-specific distinctions in the human ApolipoproteinE (ApoE) locus represent the best characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform ApoEε2 is associated with reduced risk, while ApoEε3 is neutral and ApoEε4 carriers exhibit increased susceptibility. Using Caenorhabditis elegans, we generated a novel suite of humanized transgenic nematodes to facilitate neuronal...

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PMID: 30683808
DOI: 10.1242/dmm.037218

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