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Article

Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC.

Circulation research - 19 Jun 2026

Ibikunle Chinyere O, Garcia Enrique J, Xue Chenyi, Kim Eunyoung, Yan Hanying, Coronel Johana, Zhu Lucie Y, Cui Jian, Chung Allen, Fries Lauren E, Sachs Nadja, Bauer Robert C, Maegdefessel Lars, Li Mingyao, Tall Alan R, Bashore Alexander C, Reilly Muredach P

Abstract excerpt

BACKGROUND: Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibroblast-like, macrophage-like, and lipid-laden foam cell-like states. However, a comprehensive multimodal characterization and understanding of the transcriptional programs driving these transitions remain...

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Foam Cells

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Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Source

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Identifiers

PMID: 42125810
DOI: 10.1161/CIRCRESAHA.125.326821
PMCID: PMC13274727

Genes

BHLHE40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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