Article

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic Plaques

2025-10-11

Abstract excerpt

<h4>Background</h4> Atherosclerosis, a leading cause of heart attack and stroke, involves intricate immune cell dynamics within arterial plaques, yet their spatial organization and functional roles remain elusive. <h4>Methods</h4> We combined Visium HD spatial transcriptomics, imaging mass cytometry, and single-cell RNA-seq across fatty-streak, advanced, and restenotic plaques to map myeloid architectures and re...

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Literature Corpus work: 0dcf5455-83b5-5962-b2c5-fe81fdd464b4
DOI: 10.1101/2025.10.09.681522

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