Article
CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly
2024-06-25
Abstract excerpt
The SWI/SNF (or BAF) complex is an essential chromatin remodeler that regulates DNA accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most frequently mutated genes in cancer and neurodevelopmental disorders. These mutations are often heterozygous loss-of-function alleles, indicating a dosage-sensitive role for SWI/SNF subunits in chromatin regulation. However, the molecular mechani...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 6a5fcb11-2d02-5696-b280-3205516f81dd
- DOI
- 10.1101/2024.06.25.600572