Article
Composition and Function of Mutant Swi/Snf Complexes.
Cell reports - 28 Feb 2017
Dutta Arnob, Sardiu Mihaela, Gogol Madelaine, Gilmore Joshua, Zhang Daoyong, Florens Laurence, Abmayr Susan M, Washburn Michael P, Workman Jerry L
Abstract excerpt
The 12-subunit Swi/Snf chromatin remodeling complex is conserved from yeast to humans. It functions to alter nucleosome positions by either sliding nucleosomes on DNA or evicting histones. Interestingly, 20% of all human cancers carry mutations in subunits of the Swi/Snf complex. Many of these mutations cause protein instability and loss, resulting in partial Swi/Snf complexes. Although several studies have shown...
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