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Article

Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes.

Science (New York, N.Y.) - 16 Jul 2021

Mashtalir Nazar, Dao Hai T, Sankar Akshay, Liu Hengyuan, Corin Aaron J, Bagert John D, Ge Eva J, D'Avino Andrew R, Filipovski Martin, Michel Brittany C, Dann Geoffrey P, Muir Tom W, Kadoch Cigall

Abstract excerpt

Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate-dependent chromatin remodelers modulate genomic architecture and gene expression and are frequently mutated in disease. However, the specific chromatin features that govern their nucleosome binding and remodeling activities remain unknown. We subjected endogenously purified mSWI/SNF complexes and their constituent assembly modules to a diverse library of...

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Identifiers

PMID: 34437148
DOI: 10.1126/science.abf8705
PMCID: PMC8390793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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