Article
Genetic elements promote retention of extrachromosomal DNA in cancer cells
2025-10-12
Abstract excerpt
<h4>ABSTRACT</h4> Extrachromosomal DNA (ecDNA) is a prevalent and devastating form of oncogene amplification in cancer 1,2 . Circular megabase-sized ecDNAs lack centromeres and segregate stochastically during cell division 3–6 yet persist over many generations. EcDNAs were first observed to hitchhike on mitotic chromosomes into daughter cell nuclei over 40 years ago with unknown mechanism 3,7 . Here we identif...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 2cbe70fc-10e5-58f2-96f7-227b0a5a3b9e
- DOI
- 10.1101/2025.10.10.681495