Article

EcDNA hubs drive cooperative intermolecular oncogene expression

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Extrachromosomal DNAs (ecDNAs) are prevalent in human cancers and mediate high oncogene expression through elevated copy number and altered gene regulation 1 . Gene expression typically involves distal enhancer DNA elements that contact and activate genes on the same chromosome 2,3 . Here we show that ecDNA hubs, comprised of ~10-100 ecDNAs clustered in the nucleus of interphase cells, drive i...

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Literature Corpus work: 19fbff5c-2387-5dd3-b790-f1537bd3a89b
DOI: 10.1101/2020.11.19.390278

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