Article

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering

2022-01-29

Abstract excerpt

<h4>Summary</h4> Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosis. It is hypothesized that their copy number, size and chromatin accessibility facilitate clustering of ecDNA and colocalization with transcriptional condensates, and that this underpins their elevat...

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Literature Corpus work: d7006efa-c3cf-58ca-b78a-e8afbde9fc9c
DOI: 10.1101/2022.01.29.478046

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