Article

Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction site

2023-05-19

Abstract excerpt

<title>Abstract</title> <p>ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA Induced Silencing Complexes (RISCs). In the RNA-bound state, AGO proteins are stable while RNA-free AGOs turn over rapidly. Molecular determinants unique to RNA-free AGO that allow its specific recognition and degradation remain unknown. Here, we show that a confined, linear region in Arabidopsis AGO1, the N-coil, is acc...

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Literature Corpus work: 6a13e683-1c2c-5587-9396-4d75100daaaf
DOI: 10.21203/rs.3.rs-2193553/v1

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