Article

RNA-guided RNA silencing by an Asgard archaeal Argonaute

2023-12-15

Abstract excerpt

Eukaryotic Argonaute proteins achieve gene repression and defense against viruses and transposons by RNA-guided RNA silencing. By contrast, known prokaryotic Argonautes adopt single-stranded DNA as guides and/or targets, leaving the evolutionary origin of RNA-guided RNA silencing elusive. Here, we show an evolutionary expansion of Asgard archaeal Argonautes (asAgos), including the discovery of HrAgo1 from the Loki...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af9c1e3a-ad6c-56dc-af59-442c0c9d0c9e
DOI: 10.1101/2023.12.14.571608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA-guided RNA silencing by an Asgard archaeal ArgonauteDOI 10.1101/2023.12.14.571608Read

Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.Semantic proximity Read

Structural and evolutionary determinants of Argonaute functionSemantic proximity Read

Plant ARGONAUTES.Semantic proximity Read

Lessons on RNA silencing mechanisms in plants from eukaryotic argonaute structures.Semantic proximity Read

The Crystal Structure of Human Argonaute2Semantic proximity Read

Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing.Semantic proximity Read

Structural basis for gene silencing by siRNAs in humansSemantic proximity Read

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.Semantic proximity Read

Advancements in Pathogen Detection: Argonaute-Based Nucleic Acid Detection TechnologySemantic proximity Read

The stepwise endonuclease activity of a thermophilic Argonaute proteinSemantic proximity Read

Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNASemantic proximity Read

Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target-silencingSemantic proximity Read