Article
The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors.
The Biochemical journal - 12 Jul 2023
Bressendorff Simon, Kausika Swathi, Sjøgaard Ida Marie Zobbe, Oksbjerg Emilie Duus, Michels Alec, Poulsen Christian, Brodersen Peter
Abstract excerpt
The effector complex of RNA interference (RNAi) contains at its core an ARGONAUTE (AGO) protein bound to a small guide RNA. AGO proteins adopt a two-lobed structure in which the N-terminal (N) and Piwi-Argonaute-Zwille (PAZ) domains make up one lobe, while the middle (MID) and Piwi domains make up the other. Specific biochemical functions of PAZ, MID and Piwi domains of eukaryotic AGO proteins have been...
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