Article

An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting

2025-10-07

Abstract excerpt

Current models of microRNA (miRNA) silencing posit that RNA-sequence rules are sufficient for canonical targeting of mRNAs by Argonaute 2 (AGO2), the central protein of the miRNA-induced silencing complex (miRISC). Using chimeric eCLIP in CRISPR-edited LIMD1 +/+ , LIMD1 +/− , and LIMD1 −/− human small airway epithelial cells (hSAECs), we reveal a transcriptome-wide dependency on LIMD1, an AGO2 adaptor, for effe...

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Literature Corpus work: fd314f3a-2c96-581c-8f2a-88cbda85674c
DOI: 10.1101/2025.10.07.680889

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