Article

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

2022-01-06

Abstract excerpt

Argonaute (Ago) proteins play a central role in post-transcriptional gene regulation through RNA interference (RNAi). Agos bind small RNAs (sRNAs) including small interfering RNAs (siRNAs) and microRNAs (miRNAs) to form the functional core of the RNA Induced Silencing Complex (RISC). The sRNA is used as a guide to target mRNAs containing either partially or fully complementary sequences, ultimately leading to down...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fc77c31-2757-5437-9fb4-ce811e60a0fb
DOI: 10.1101/2022.01.06.475261

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target releaseDOI 10.1101/2022.01.06.475261Read

Phosphorylation of human Argonaute proteins affects small RNA binding.Semantic proximity Read

Phosphorylation of Argonaute proteins: regulating gene regulators.Semantic proximity Read

Intensive and Specific Feedback Self-control of the Argonautes and MicroRNA Targeting ActivitySemantic proximity Read

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.Semantic proximity Read

Structural basis for differential targeting properties of small RNAs in plants and animalsSemantic proximity Read

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.Semantic proximity Read

Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target-silencingSemantic proximity Read

Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its function.Semantic proximity Read

Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction siteSemantic proximity Read

Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction siteSemantic proximity Read

Phosphorylation by CK2 increases the SUMO-dependent activity of Cytomegalovirus transactivator IE2Semantic proximity Read

The Crystal Structure of Human Argonaute2Semantic proximity Read