Article
Lessons on RNA silencing mechanisms in plants from eukaryotic argonaute structures.
The Plant cell - 1 Jan 2013
Poulsen Christian, Vaucheret Hervé, Brodersen Peter
Abstract excerpt
RNA silencing refers to a collection of gene regulatory mechanisms that use small RNAs for sequence specific repression. These mechanisms rely on ARGONAUTE (AGO) proteins that directly bind small RNAs and thereby constitute the central component of the RNA-induced silencing complex (RISC). AGO protein function has been probed extensively by mutational analyses, particularly in plants where large allelic series of...
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