Article

Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction site

2022-10-23

Abstract excerpt

<h4>ABSTRACT</h4> ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA Induced Silencing Complexes (RISCs). In the RNA-bound state, AGO proteins are stable while RNA-free AGOs turn over rapidly. Molecular determinants unique to RNA-free AGO that allow its specific recognition and degradation remain unknown. Here, we show that a confined, linear region in Arabidopsis AGO1, the N-coil, is accessible t...

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Literature Corpus work: 05c6c49d-5282-541f-8f39-d10227864102
DOI: 10.1101/2022.10.22.513346

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