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Article

Development of super-specific epigenome editing by targeted allele-specific DNA methylation.

Epigenetics & chromatin - 21 Oct 2023

Rajaram Nivethika, Kouroukli Alexandra G, Bens Susanne, Bashtrykov Pavel, Jeltsch Albert

Abstract excerpt

BACKGROUND: Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) refers to the targeted methylation delivery only to one allele of a locus. In the context of diseases caused by a...

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Identifiers

PMID: 37864244
DOI: 10.1186/s13072-023-00515-5
PMCID: PMC10589950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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