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Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells

9 Dec 2024

Abstract excerpt

The human body function requires crosstalk between different tissues. An essential crosstalk is in the neuromusculoskeletal (NMS) axis involving neural, muscular, and skeletal tissues, which is challenging to model using human cells. Here, we describe the generation of three-dimensional, NMS tri-tissue organoids (hNMSOs) from human pluripotent stem cells through a co-development strategy. Staining, single-nucleus...

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PMID: 39657678
DOI: 10.1016/j.stem.2024.11.005

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