Article

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

2021-11-19

Abstract excerpt

<h4>SUMMARY</h4> Human mutations in mitochondrial-associated genes are associated with inflammatory diseases and susceptibility to infection. However, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele Lrrk2 G2019S (leucine-rich repeat kinase 2) promotes mitochondrial hyper-fission, depolarization, and oxidative stress in macr...

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Literature Corpus work: 6980b569-ca06-544b-80e4-88ab7454f5fd
DOI: 10.1101/2021.11.18.469014

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