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Article

LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.

eLife - 14 Feb 2020

Weindel Chi G, Bell Samantha L, Vail Krystal J, West Kelsi O, Patrick Kristin L, Watson Robert O

Abstract excerpt

The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggesting LRRK2 also controls immunity. We demonstrate that loss of LRRK2 in macrophages induces elevated basal levels of type I interferon (IFN) and interferon stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mitochondria

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Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 32057291
DOI: 10.7554/eLife.51071
PMCID: PMC7159881

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