Article

LRRK2 regulates innate immune responses and neuroinflammation during <i>Mycobacterium tuberculosis</i> infection

2019-07-11

Abstract excerpt

<h4>SUMMARY</h4> Despite many connections between mutations in leucine-rich repeat kinase 2 ( LRRK2 ) and susceptibility to mycobacterial infection, we know little about its function outside of the brain, where it is studied in the context of Parkinson’s Disease (PD). Here, we report that LRRK2 controls peripheral macrophages and brain-resident glial cells’ ability to respond to and express inflammatory molecule...

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Literature Corpus work: 9681f160-31be-5b0f-89e2-fc334c457497
DOI: 10.1101/699066

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